lindane
Identification (Source:EPA,EU)
| ID |
183 |
| Name |
lindane |
| CAS |
58-89-9 |
| IUPAC |
1α,2α,3β,4α,5α,6β-hexachlorocyclohexane |
| Inchi |
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+ |
| CIPAC |
488 |
| EPA Code |
009001 |
| Formula |
C6H6Cl6 |
| SMILES |
ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl |
| Status |
Not Approved |
Classification
Properties (Source:PubChem)
| Molecular Weight |
290.83 |
| Physical State |
Colourless crystals |
| AlogP |
4.163 |
| H-Bond Donor |
0 |
| H-Bond Acceptor |
0 |
| Surface Area |
223.77 |
| Polar Surface Area |
0.0 |
Structure
Ecotoxicology (Source:PPDB,IPM)
| Species |
Method |
Study Time |
Dose Type |
Value |
| Algae |
Acute |
72 hour |
EC50, growth |
2.5 mg l-1 |
| Algae |
Chronic |
96 hour |
NOEC, growth |
1.9 mg l-1 |
| Aquatic crustaceans |
Acute |
96 hour |
LC50 |
0.0063 mg l-1 |
| Aquatic invertebrates |
Acute |
48 hour |
EC50 |
1.6 mg l-1 |
| Aquatic invertebrates |
Chronic |
21 day |
NOEC |
0.0002 mg l-1 |
| Aquatic plants |
Acute |
7 day |
EC50, biomass |
0.027 mg l-1 |
| Birds |
Acute |
|
LD50 |
122 mg kg-1 |
| Earthworms |
Acute |
14 day |
LD50 |
68 mg kg-1 |
| Fish |
Chronic |
21 day |
NOEC |
0.003 mg l-1 |
| Fish |
Acute |
96 hour |
LC50 |
0.0029 mg l-1 |
| Honeybees |
Acute |
48 hour |
LD50 |
0.56 μg bee-1 |
| Mammals |
Acute oral |
|
LD50 |
88 mg kg-1 |
| Mammals |
Short term dietary |
|
NOEL |
4 ppm diet |
| Mammals |
Short term dietary |
|
NOEL |
0.3 mg kg-1 |
| Sediment dwelling organisms |
Acute |
96 hour |
LC50 |
0.04 mg l-1 |
|
Bio-concentration factor |
|
CT50 |
Not available days |
|
Bio-concentration factor |
|
BCF |
1300 |
Related targets
| Target Name |
RScore (About this table) |
|
|
Connexin 43
|
878(8,14,15,53) |
Details |
|
chloride channel (protein family or complex)
|
709(8,9,9,39) |
Details |
|
GABA B receptors
|
598(7,8,8,8) |
Details |
|
gamma aminobutyric acid receptor (protein family or complex)
|
531(5,8,8,41) |
Details |
|
cytochrome P450 (protein family or complex)
|
474(4,7,12,39) |
Details |
|
PLA2
|
246(3,3,3,6) |
Details |
|
adenylate cyclase
|
243(3,3,3,3) |
Details |
|
superoxide dismutase
|
376(2,7,12,41) |
Details |
|
catalase
|
377(2,6,15,52) |
Details |
|
c fos
|
338(2,6,11,33) |
Details |
|
beta adrenergic receptors (protein family or complex)
|
230(2,4,5,5) |
Details |
|
phospholipase C
|
227(2,4,4,7) |
Details |
|
glutathione reductase
|
194(2,2,5,19) |
Details |
|
androgen receptors
|
165(2,2,2,5) |
Details |
|
calmodulin
|
256(1,6,8,16) |
Details |
|
calcium channel (protein family or complex)
|
214(1,5,6,9) |
Details |
|
cytochrome c
|
193(1,4,6,13) |
Details |
|
caspase 3
|
150(1,3,3,10) |
Details |
|
Acetylcholinesterase
|
168(1,2,7,33) |
Details |
|
SRBC
|
121(1,2,3,6) |
Details |
|
TNFalpha
|
119(1,2,3,4) |
Details |
|
steroidogenic acute regulatory protein
|
118(1,2,3,3) |
Details |
|
P450scc
|
114(1,2,2,4) |
Details |
|
NR2B
|
113(1,2,2,3) |
Details |
|
glycogen phosphorylase
|
112(1,2,2,2) |
Details |
|
complex is
|
112(1,2,2,2) |
Details |
|
N acetyltransferase
|
100(1,1,4,5) |
Details |
|
CIP1
|
92(1,1,2,7) |
Details |
|
phosphodiesterase
|
87(1,1,2,2) |
Details |
|
ER beta
|
86(1,1,1,6) |
Details |
|
IL 5
|
84(1,1,1,4) |
Details |
|
CYP3A
|
83(1,1,1,3) |
Details |
|
GABA at
|
82(1,1,1,2) |
Details |
|
ceruloplasmin
|
82(1,1,1,2) |
Details |
|
ERK1
|
82(1,1,1,2) |
Details |
|
TP53
|
82(1,1,1,2) |
Details |
|
vasoactive intestinal peptide
|
81(1,1,1,1) |
Details |
|
PGs 2
|
81(1,1,1,1) |
Details |
|
novel proteins
|
81(1,1,1,1) |
Details |
|
acinus
|
81(1,1,1,1) |
Details |
|
sulfatase
|
81(1,1,1,1) |
Details |
|
glutathione S transferase
|
167(0,4,7,32) |
Details |
|
NMDA receptor (protein family or complex)
|
125(0,4,4,5) |
Details |
|
glucose 6 phosphate dehydrogenase
|
111(0,3,5,11) |
Details |
|
MAPK (protein family or complex)
|
98(0,3,3,8) |
Details |
|
lactate dehydrogenase (protein family or complex)
|
87(0,2,5,12) |
Details |
|
brains
|
73(0,2,3,8) |
Details |
|
brain derived neurotrophic factor
|
68(0,2,2,8) |
Details |
|
protein kinase C (protein family or complex)
|
66(0,2,2,6) |
Details |
|
CA1
|
66(0,2,2,6) |
Details |
|
MEK1
|
63(0,2,2,3) |
Details |
|
ATPase
|
65(0,1,3,25) |
Details |
|
zonula occludens 1
|
48(0,1,2,13) |
Details |
|
PGDH
|
43(0,1,3,3) |
Details |
|
CYP2B
|
38(0,1,2,3) |
Details |
|
clusterin
|
38(0,1,2,3) |
Details |
|
cholinesterases
|
38(0,1,1,8) |
Details |
|
glycine receptor (protein family or complex)
|
37(0,1,1,7) |
Details |
|
sodium channel (protein family or complex)
|
36(0,1,1,6) |
Details |
|
NADPH cytochrome P450 reductase
|
36(0,1,1,6) |
Details |
|
transferase
|
34(0,1,1,4) |
Details |
|
albumin
|
34(0,1,1,4) |
Details |
|
phospholipase A2
|
33(0,1,1,3) |
Details |
|
isocitrate dehydrogenase
|
33(0,1,1,3) |
Details |
|
lysozyme
|
33(0,1,1,3) |
Details |
|
xanthine oxidase
|
32(0,1,1,2) |
Details |
|
Bcl xL
|
32(0,1,1,2) |
Details |
|
LAMP1
|
32(0,1,1,2) |
Details |
|
phosphoinositide phospholipase C
|
31(0,1,1,1) |
Details |
|
phosphatidylinositol specific
|
31(0,1,1,1) |
Details |
|
kit ligand
|
31(0,1,1,1) |
Details |
|
Beclin 1
|
31(0,1,1,1) |
Details |
|
Tet 1
|
31(0,1,1,1) |
Details |
|
peripheral type benzodiazepine receptor
|
31(0,1,1,1) |
Details |
|
apoptosis related proteins
|
31(0,1,1,1) |
Details |
|
androgen binding protein
|
31(0,1,1,1) |
Details |
|
cyclooxygenase 2
|
31(0,1,1,1) |
Details |
|
chitinase
|
31(0,1,1,1) |
Details |
|
muscles
|
42(0,0,4,22) |
Details |
|
estrogen receptor
|
33(0,0,0,33) |
Details |
|
glutamyl transpeptidase
|
30(0,0,3,15) |
Details |
|
alkaline phosphatase
|
24(0,0,3,9) |
Details |
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