| 20233601 |
Rezg R, Mornagui B, Benahmed M, Chouchane SG, Belhajhmida N, Abdeladhim M, Kamoun A, El-Fazaa S, Gharbi N: Malathion exposure modulates hypothalamic gene expression and induces dyslipidemia in Wistar rats. Food Chem Toxicol. 2010 Mar 15.
Exposure to organophosphate (OP) pesticides is virtually ubiquitous. These inevitable agents are neurotoxicants, but recent evidence also points to lasting effects on carbohydrate metabolism. The aim of this study was to investigate the effects of a subchronic exposure to malathion, an OP insecticide, on some molecular and metabolic parameters. Malathion at 100mg/kg was administered by gavage to Wistar rats during 32days. Results of this study indicate a significant decrease in hypothalamic corticotropin-releasing hormone mRNA, of Malathion-treated rats. This result, in accordance with that of diabetic type 2 rat model, may be due to very potent negative feedback effects of glucocorticoids on hypothalamo-pituitary-adrenal (HPA) axis activity. In addition, we have recorded a significant increase in hypothalamic inducible NOsynthase mRNA which probably enhances the negative feedback. These alterations are accompanied with hypertriglyceridemia that may be a favourable condition to insulin resistance. Thus, results of the present study suggest that Malathion can be considered as an important risk factor in the development of diabetes type 2, which prevalence increased substantially in our country and around the world. Clearly, we need to focus further research on the specific incidences of hazardous food chemical contaminant that might be contributing to epidemic health perspectives. |
6(0,0,1,1) |