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Giermaziak H: [Organic changes in rabbits and rats in phosphorothioaliphatic compound poisoning. Med Pr. 1989;40(4):228-37.
III. The histomorphologic picture of selected internal organs, especially the myocardium, in rats and rabbits in phosphorothioaliphatic pound poisoning treated with oximes]. Pathomorphological changes of the cardiac muscle of experimental rabbits and rats intoxicated with Intration were traced. Diffuse ischaemic lesions such as the presence of large quantities of mitochondria, contraction nodes and droplet necrosis were observed. These lesions result: from the toxic effect of pesticides on myocytes and inhibition of cholinesterases as well as from nonphysiologically great activity of lysosome enzymex which are also responsible for necrotic lesions in the cardiac muscle. Excessively high PAM doses administered to animals intoxicated with pesticide result in lesions in the cardiac muscle of rabbits and rats which are greater than after administering an insectide alone. Toxobidin, a multi-function compound, doses not possess such negative properties as PAM. |
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