| 2597761 |
Predtechenskii MB, Elaeva NL, Smirnova ZI: [Modification of selective adsorption of muscarinic antagonists in cerebral membranes during chlorophos poisoning]. Farmakol Toksikol. 1976 Jan-Feb;39(1):35-9.
Using radioligand assay it was demonstrated that chlorophos intoxication produced inhibiting effect on the kinetics of membrane binding of 3H3-quinuclidinylbenzilate and 14C-cyclosil in the brain. Cholinesterase reactivator dipyroxime was shown to induce normalization of the cyclosyl specific binding kinetics. It seems to be justified to propose that cooperative action of cholinolytic agents and cholinesterase reactivator at the level of m-cholinoreceptors in the course of intoxication may be one of the mechanisms of the potentiation of therapeutic effects of these drugs. |
2(0,0,0,2) |