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Matkovics B, Szabo L, Ivan J, Gaal I: Some further data on the effects of two organophosphate pesticides on the oxidative metabolism in the liver. Am J Health Syst Pharm. 1999 Mar 1;56(5):427-32.
Sumithion is the most active cholinesterase inhibitor. The cholinesterase inhibiting action of the organophosphates (OPs) is better compensated by vitamin E in normal animals, but by vitamin A in vitamin A-deficient animals. The lipid peroxidation (LP) is enhanced by the antioxidant vitamins in the liver of normal rats; although they decrease it in the liver of vitamin A-deficient animals, in no case do they prevent the LP-enhancing effect of the OPs examined. The OPs examined inhibit protein synthesis in the liver of vitamin A-deficient animals. |
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