| 18023348 |
Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E: 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):309-12. Epub 2007 Nov 19.
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats. |
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