| 9622602 |
Hodson EA, Ashley CC, Hughes AD, Lymn JS: Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator. Biochim Biophys Acta. 1998 May 27;1403(1):97-101.
The regulation of Phospholipase C (PLC) delta activity remains obscure. These studies show that PLCdelta1 activity is significantly enhanced by both guanosine thiotriphosphate (GTPgammaS) and Clostridium botulinum exoenzyme C3 (C3) but not by aluminium fluoride. C3 ADP ribosylated a 21-kDa protein in the PLCdelta1 preparation and Western blotting identified rhoA in these samples. RhoA acts as an inhibitory modulator of PLCdelta activity. |
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