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Wettwer E: Is there a functional correlate of Kv1.5 in the ventricle of canine heart and what would it mean for the use of I (Kur) blockers?. Br J Pharmacol. 2007 Nov;152(6):835-7. Epub 2007 Sep 17.
The cardiac ultrarapid outward current I (Kur), encoded by KCNA5, is of special pharmacological interest, because it is considered to be atrium-specific. I (Kur) has therefore become a target in the therapy of atrial tachyarrhythmias. However, the concept of atrium specificity is only valid if a functional I (Kur) current is in fact absent from the ventricle. However, new work has detected a I (Kur)-like current in canine ventricular myocytes, sensitive to 4-aminopyridine and suppressed by the I (Kur) blocker DPO-1, findings that support the existence of a functional ventricular I (Kur). These indications are, however, indirect and more effort is needed to clarify unequivocally the putative role of an expectedly small I (Kur) component in the ventricle. |
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