| 17134289 |
Labonne A, Kribber T, Hintermann L: Highly active in situ catalysts for anti-Markovnikov hydration of terminal alkynes. Org Lett. 2006 Dec 7;8(25):5853-6.
The anti-Markovnikov hydration of terminal alkynes to give aldehydes is catalyzed by complexes derived in situ from air-stable [CpRu (eta6-naphthalene)] PF6 (C) and 6-aryl-2-diphenylphosphinopyridines (L). Ligands L are readily available from a modular synthesis. Increasing the size of the ligand C-6 aryl group in the order R = Ph < mesityl < 2,4,6-triisopropylphenyl < (2,4,6-triphenyl) phenyl gave hydration catalysts of highest known activity. [reaction: see text] |
31(0,1,1,1) |