| 15716550 |
Glasauer S, Kalla R, Buttner U, Strupp M, Brandt T: 4-aminopyridine restores visual ocular motor function in upbeat nystagmus. . J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):451-3.
The effect of the potassium channel blocker 4-aminopyridine (4-AP) on spontaneous upbeat nystagmus (UBN) was investigated with the search coil technique during fixation in different gaze positions and smooth pursuit in a patient before and after ingestion of 10 mg 4-AP. UBN was reduced from 8.6 deg/s to 2.0 deg/s by 4-AP causing subjective relief from distressing oscillopsia, and impaired upward smooth pursuit was restored (gains: before medication 0.38; after medication 0.86). In the dark, UBN was slightly stronger and not affected by 4-AP. We propose that 4-AP improved the function of cerebellar pathways that mediate gaze holding and smooth pursuit by intensifying the excitability of cerebellar Purkinje cells. |
6(0,0,1,1) |