Protein Information

ID 318
Name Potassium channel (protein family or complex)
Synonyms Potassium channel

Compound Information

ID 332
Name 4-aminopyridine
CAS 4-pyridinamine

Reference

PubMed Abstract RScore(About this table)
16554965 Ozdem SS, Yalcin O, Meiselman HJ, Baskurt OK, Usta C: The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries. Cardiovasc Drugs Ther. 2006 Apr;20(2):123-7.
We investigated both the effect of levosimendan and the role of various potassium channels in KCl-precontracted rat small mesenteric arteries. Levosimendan (10 (-6)-10 (-3) M) or cromakalim (CRO, 10 (-7)-10 (-4) M) produced concentration-dependent relaxation responses in small mesenteric arteries precontracted by 30 mM KCl. The relaxant responses to levosimendan in KCl-precontracted arteries did not differ significantly between endothelium-intact and endothelium-denuded preparations. Incubation of rat small mesenteric arterial segments with ATP-dependent potassium channel (KATP) blocker glibenclamide (GLI, 10 (-6) M) for 30 min significantly inhibited the relaxant responses to both levosimendan and CRO. Neither the Ca (2+)-activated potassium channel (KCa) blocker iberiotoxin (10 (-7) M) nor the voltage-dependent potassium channel (KV) blocker 4-aminopyridine (5 mM) incubation for 30 min caused significant alterations in relaxant responses to levosimendan in KCl-precontracted small mesenteric arteries. These findings suggested that levosimendan-induced relaxation responses in isolated rat small mesenteric arteries were neither depended on endothelium nor inhibited by the blockers of KV or KCa but, they rather seem to depend on the activation of KATP.
1(0,0,0,1)