Protein Information

ID 2794
Name pyridine nucleotide transhydrogenase
Synonyms NNT; NNT protein; Nicotinamide nucleotide transhydrogenase; Pyridine nucleotide transhydrogenase; NNT proteins; Nicotinamide nucleotide transhydrogenases; Pyridine nucleotide transhydrogenases

Compound Information

ID 1341
Name rotenone
CAS

Reference

PubMed Abstract RScore(About this table)
1757194 Goyal N, Gupta S, Katiyar JC, Srivastava VM: NADH oxidase and fumarate reductase of Ancylostoma ceylanicum. Int J Parasitol. 1991 Oct;21(6):673-6.
Ancylostoma ceylanicum, the hookworm parasite of cat, dog and man, was found to contain NADH and/or NADPH oxidase as well as fumarate reductase activities. Both the enzyme systems were predominantly located in the membranes of mitochondrial-rich preparations. The membranes also exhibited the presence of a reduced pyridine nucleotide transhydrogenase activity which transferred hydrogen from NADPH to NAD. Amongst respiratory inhibitors, rotenone (Site I inhibitor) markedly depressed both NADH oxidase and fumarate reductase while others, namely antimycin-A, KCN and azide, had a lesser effect.
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