| 19786349 |
Zhou Y, Liu G, Chen J, Reddy PS, Yoon IS, Zhang M, Zhang B, Barber JR, Ng SC: Pyrimido [5,4-e][1,2,4] triazine-5,7 (1H,6H)-dione derivatives: their cytoprotection effect from rotenone toxicity and preliminary DMPK properties. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6114-8. Epub 2009 Sep 10.
Pyrimido [5,4-e][1,2,4] triazine-5,7 (1H,6H)-dione derivatives exhibited potent cytoprotective effect from rotenone toxicity. Lead optimization focused on the CC50/EC50 ratio and DMPK properties led to the overall improvement of the compound profile of this series with high CC50/EC50 ratio (92 for 1f), good metabolic stability in rat microsomes and medium to high aqueous solubility. |
82(1,1,1,2) |