| 15240412 |
Gille G, Hung ST, Reichmann H, Rausch WD: Oxidative stress to dopaminergic neurons as models of Parkinson's disease. Ann N Y Acad Sci. 2004 Jun;1018:533-40.
The effects of exogenous toxins (MPP (+), rotenone) and potentially neurotoxic properties of levodopa (L-DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP (+)-toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q (10) (CoQ (10)) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP (+) is demonstrated. |
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