Protein Information

ID 40
Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

ID 1582
Name indoxacarb
CAS

Reference

PubMed Abstract RScore(About this table)
11455646 McCann SF, Annis GD, Shapiro R, Piotrowski DW, Lahm GP, Long JK, Lee KC, Hughes MM, Myers BJ, Griswold SM, Reeves BM, March RW, Sharpe PL, Lowder P, Barnette WE, Wing KD: The discovery of indoxacarb: oxadiazines as a new class of pyrazoline-type insecticides. Pest Manag Sci. 2001 Feb;57(2):153-64.
The evolution of the insecticidal pyrazoline moiety that was originally discovered in 1972 has led to the discovery of a new crop insecticide, indoxacarb, which is the first commercialized pyrazoline-type sodium-channel blocker. Both monocyclic and fused-tricyclic pyrazolines and pyridazines, as well as structurally related semicarbazones were examined prior to the discovery of analogous tricyclic oxadiazines which had similarly high activity as well as favorable environmental dissipation rates and low toxicity to non-target organisms. The eventual leading candidate, DPX-JW062, was originally obtained as a racemic molecule, but a chiral synthesis was developed which produces material that is 50% ee in the insecticidal (+)-S-enantiomer (DPX-MP062, indoxacarb).
6(0,0,1,1)