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Yu W, Shen F, Ma Z: [Observation of therapeutic effect of Salviae miltiorrhiza and cytosine diphosphate-choline injection on patients with hypertensive cerebral hemorrhage]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Feb;20(2):94-6.
OBJECTIVE: To assess the effect of Salviae miltiorrhiza (SM) injection in the treatment of hypertensive cerebral hemorrhage (HCH). METHODS: Fifty-one cases (age 50-78 years, 61.2 years on average) of HCH were randomly divided into three groups (SM + cytosine diphosphate-choline (CDP-C) group and para-aminomethyl benzoic acid (PAMBA) + CDP-C group as treated group, CDP-C group as control group) to observe the outcome of the clinical treatment, hematoma absorbability and changes of ADP-platelet agglutination rate (Pag), prothrombin time (PT) and function of the liver and kidney. RESULTS: The rate of good result (GR) and moderate disability (MD) in SM group was 85.71% with the method of Glasgow outcome score (GOS), others were 47.06% and 61.54% separately, they have significant difference, P < 0.05. Among them, SM group had best result. Compared the rate of hematoma absorbability of SM group with that of PAMBA, CDP-C groups, the difference was significant, P < 0.05. It did not affect the platelet coagulative function in SM group. CONCLUSION: SM injection could effectively improve the condition of patients with HCH, and without any side effect. It is worthwhile to be used in the clinical practice. |
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