| 12018584 |
Nag M, Nandy N: Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Indian J Exp Biol. 2001 Aug;39(8):802-6.
Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO. |
82(1,1,1,2) |