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Sun M, Xu PP, Ren Y, Li YF, Zhong YF, Yan H: [Protective effect of melatonin on oxidative damage by deltamethrin in rat brain]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007 Mar;25(3):155-8.
OBJECTIVE: To study the potential protective effect of melatonin on the oxidative damage induced by deltamethrin in cerebral cortex, hippocampus and cerebellum of rats. METHODS: 35 male wistar rats were randomly divided into five groups (seven rats per group): olive oil control, deltamethrin-treated (12.5 mg/kg), melatonin (25.0 mg/kg) and deltamethrin plus melatonin (25.0 mg/kg , 2.5 mg/kg respectively) group. Levels of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione (GSH) in cerebral cortex, hippocampus and cerebellum were determined after 5 days of DM treatments. RESULTS: MDA content in cerebral cortex, hippocampus and cerebellum tissue of the DM-treated rats were significantly higher than those in control group, and compared with DM-treated group, MDA content in those tissue of MT + DM-treated group have significantly decreased after 5 days of DM exposure (P < 0.05). Activities of GSH-Px in DM-treated group were significantly lower than those in control group, and those in the MT + DM group were significantly higher than DM group (P < 0.05). CONCLUSION: DM can induce the oxidative damage in rat brain and melatonin has protective effects on deltamethrin-induced oxidative damage in hippocampus, cerebral cortex and cerebellum of rats. |
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