| 8920739 |
Leng G, Kuhn KH, Idel H: Biological monitoring of pyrethroid metabolites in urine of pest control operators. Toxicol Lett. 1996 Nov;88(1-3):215-20.
Due to their low mammalian toxicity but high insectical activity, pyrethroids are increasingly used for pest control. The objective of the present study was the development of a biological monitoring program to determine exposure to pyrethroids. A diastereoselective detection of the major pyrethroid metabolites cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid, cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid, 3-phenoxybenzoic acid and fluorophenoxybenzoic acid by capillary gas chromatography in combination with mass selective detection was applied. The limits of determination ranged between 0.5 and 1 microgram/l urine, depending on the metabolite concerned. It was demonstrated that pyrethroid metabolites were detectable in urine for a period of elimination up to 3.5 days after exposure to cyfluthrin. Fluorophenoxybenzoic acid was shown to be a suitable biomarker for exposure to cyfluthrin. The presented method was adequate for monitoring pyrethroids in occupationally exposed subjects. |
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