Protein Information

ID 40
Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

ID 268
Name cypermethrin
CAS cyano(3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference

PubMed Abstract RScore(About this table)
7491497 Taylor MF, Shen Y, Kreitman ME: A population genetic test of selection at the molecular level. Science. 1995 Dec 1;270(5241):1497-9.
The role of natural selection in molecular evolution has been inferred primarily by rejection of null hypotheses based on neutral theory, rather than by acceptance of specific predictions based on selection. In this report, a population genetic test of a specific prediction for selection on DNA polymorphism is presented. Pyrethroid insecticide use constitutes an experiment for which form of selection and molecular target (voltage-gated sodium channels) are both known. As predicted, differential pyrethroid selection on tobacco budworm populations generated significant geographic heterogeneity in sodium channel marker allele frequencies, compared with arbitrary loci.
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