| 879915 |
Gokhale VS, Bapat VM, Kanitkar SV, Kulkarni SD: Altered sensitivity to acetylcholine during chronic administration of organophosphorus anticholinesterase (fenthion) in albino mice. Arch Int Pharmacodyn Ther. 1977 Apr;226(2):331-8.
Tissue sensitivity to acetylcholine during chronic administration of fenthion was assessed in mice. Fenthion was injected intra-muscularly every fourth day and experiments were carried out at various intervals. The parameters selected for testing cholinergic effects were, acetyl choline-induced contraction of isolated ileum and salivary secretion in vivo. In both types of experiments an initial supersensitivity followed by tolerance to acetylcholine were observed. The underlying mechanisms are discussed. |
6(0,0,1,1) |