| 1028593 |
Voitenko GA, Larionov VG: [Toxic effect of phosphamide after simultaneous entrance into the body through the gastrointestinal tract and respiratory organs]. Farmakol Toksikol. 1976 Sep-Oct;39(5):622-5.
The experiment involved an investigation into the action of O,O-dimethyl-S-(N-methyl-carbomoilmethyl)-dithiophosphate (phosphamide), used at the level of the liminal dose (4 mg/kg) and in a concentration of 1.9 mg/m3, as compared with the effect of 1/2 of the liminal dose and 1/2 of the thereshold concentration. Both were simultaneously introduced into the organism of test albino rats for a period of 4 months and their complex action showed an intensification of the toxic effect. In evidence was also a more marked anticholinesterase action, a higher level of the insecticide in biological substrates and greater changes of hematological indices. |
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