Protein Information

ID 2826
Name CDK5
Synonyms CDK 5; CDK5; CDK5 protein; Cell division kinase 5; Cell division protein kinase 5; Cyclin dependent kinase 5; PSSALRE; Serine/threonine protein kinase PSSALRE…

Compound Information

ID 1700
Name kinetin
CAS

Reference

PubMed Abstract RScore(About this table)
19944738 Choi HS, Chung SH: Roscovitine increases intracellular calcium release and capacitative calcium entry in PC12 cells. Neurosci Lett. 2010 Jan 18;469(1):141-4. Epub 2009 Nov 26.
Cyclin-dependent kinase 5 (Cdk5), which is activated by the non-cyclin regulator p35 or p39, is a proline-directed serine/threonine kinase that is implicated in many physiological and pathological processes. Here, we studied calcium signaling using the fluorescent cytosolic calcium indicator, Fura-4, in NGF-differentiated PC12 cells treated with roscovitine, a Cdk5 inhibitor. As compared to the control cells, the roscovitine-treated cells significantly potentiated intracellular calcium release by membrane depolarization (high K (+)) or through thapsigargin. In addition, roscovitine increased the magnitude of capacitative calcium entry (CCE), i.e., a calcium influx mechanism triggered by the depletion of intracellular calcium stores. Notably, roscovitine markedly slowed the rate of Ca (2+) removal from the plasma membrane. These results suggest that Cdk5 regulates intracellular calcium homeostasis and that the dysregulation of Cdk5 may contribute to disease pathogenesis by perturbing cellular Ca (2+) signaling.
1(0,0,0,1)