| 16386795 |
Travnicek Z, Krystof V, Sipl M: Zinc (II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity. J Inorg Biochem. 2006 Feb;100(2):214-25. Epub 2006 Jan 4.
The synthesis, characterization and biological activity of the first zinc (II) complexes with potent inhibitors of cyclin-dependent kinases (CDKs) derived from 6-benzylaminopurine are described. Based on the results following from elemental analyses, infrared, NMR and ES+MS (electrospray mass spectra in the positive ion mode) spectroscopies, conductivity data, thermal analysis and X-ray structures, the tetrahedral Zn (II) complexes of the compositions [Zn (Olo) Cl (2)](n) (1), [Zn (iprOlo) Cl (2)](n) (2), [Zn (BohH (+)) Cl (3)] x H (2) O (3) and [Zn (iprOloH (+)) Cl (3)] x H (2) O (4) have been prepared, where Olo=2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine (Olomoucine), iprOlo=2-(2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (i-propyl-Olomoucine), Boh=2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine (Bohemine). The 1D-polymeric chain structure for [Zn (Olo) Cl (2)](n) (1) as well as the monomeric one for [Zn (BohH (+)) Cl (3)] x H (2) O (3) and [Zn (iprOloH (+)) Cl (3)] x H (2) O (4) have been revealed unambiguously by single crystal X-ray analyses. The 1D-polymeric chain of 1 consists of Zn (Olo) Cl (2) monomeric units in which the Zn (II) ion is coordinated by two chlorine atoms and one oxygen atom of the 2-hydroxyethylamino group of Olomoucine. The next monomeric unit is bonded to Zn (II) through the N7 atom of a purine ring. Thus, each of Zn (II) ions is tetrahedrally coordinated and a ZnCl (2) NO chromophore occurs in the complex 1. The complexes 3 and 4 are mononuclear species with a distorted tetrahedral arrangement of donor atoms around the Zn (II) ion with a ZnCl (3) N chromophore. The corresponding CDK inhibitor, i.e., both Boh and iprOlo, is coordinated to Zn (II) via the N7 atom of the purine ring in 3 and 4. The cytotoxicity of the zinc (II) complexes against human melanoma, sarcoma, leukaemia and carcinoma cell lines has been determined as well as the inhibition of the CDK2/cyclin E kinase. A relationship between the structure and biological activity of the complexes is also discussed. |
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