| 3401257 |
Deli E, Kiss Z: Effect of parathion and methylparathion on protein content of chicken embryo muscle in vivo. Biochem Pharmacol. 1988 Sep 1;37(17):3251-6.
Chicken eggs were treated with 0.4 per cent solutions of parathion or methylparathion for four or eight days, and the two-dimensional gel electrophoretic protein pattern of cervical muscles of eighteen days old embryos was analyzed. Both compounds significantly decreased the content of alpha-actinin, alpha-tubulin and beta-tubulin after four days treatment, and, in addition, that of three other related proteins (gamma-proteins) after eight days treatment. Under in vitro phosphorylating conditions, both methylparathion and parathion specifically inhibited the phosphorylation of one isoform of beta-tubulin. Data suggest that the muscle-damaging effects of organophosphorous insecticides, such as parathion and its derivates, may be related to the decrease of tissue content of certain cytoskeletal proteins. |
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