parathion

Identification (Source:EPA,EU)

ID 228
Name parathion
CAS 56-38-2
IUPAC
Inchi InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
CIPAC 10
EPA Code 057501
Formula C10H14NO5PS
SMILES S=P(Oc1ccc(cc1)[N+]([O-])=O)(OCC)OCC
Status Not Approved

Classification

Mode of Action Non-systemic with contact, stomach and some respiratory action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type Insecticide, Acaricide
Chemical Group Organophosphate
Classification phenyl organothiophosphate insecticides
organothiophosphate acaricides
organothiophosphate insecticides

Properties (Source:PubChem)

Molecular Weight 291.26
Physical State Pale yellow liquid
AlogP 2.902
H-Bond Donor 0
H-Bond Acceptor 6
Surface Area 276.76
Polar Surface Area 115.41

Structure



ChemMapper Search Option (Docunmentation of ChemMapper)

3D similarity method

2D similarity method

Compound Database



Bioactivity Database

KEGG (5,928)

PDB (7,072)


Similarity Threshold

Ecotoxicology (Source:PPDB,IPM)

Species Method Study Time Dose Type Value
Algae Acute 72 hour EC50, growth 0.5 mg l-1
Aquatic crustaceans Acute 96 hour LC50 0.00011 mg l-1
Aquatic invertebrates Acute 48 hour EC50 0.0025 mg l-1
Birds Acute LD50 2.1 mg kg-1
Earthworms Acute 14 day LD50 267 mg kg-1
Fish Acute 96 hour LC50 1.5 mg l-1
Honeybees Acute 48 hour LD50 0.04 μg bee-1
Mammals Acute oral LD50 2 mg kg-1
Mammals Short term dietary NOEL 2 ppm diet
Sediment dwelling organisms Acute 96 hour LC50 0.14 mg l-1
Bio-concentration factor CT50 Not available days
Bio-concentration factor BCF 40

Related targets

Target Name RScore (About this table)
Acetylcholinesterase 6566(52,105,138,651) Details
cholinesterase 5413(35,98,147,478) Details
cytochrome P450 (protein family or complex) 2569(23,42,48,129) Details
albumin 735(8,10,12,25) Details
CYP3A 773(7,13,14,28) Details
glutathione S transferases 527(5,7,13,37) Details
caspase 3 328(4,4,4,8) Details
adenylyl cyclase 246(3,3,3,6) Details
Paraoxonase 614(2,10,20,164) Details
beta adrenergic receptor (protein family or complex) 294(2,6,7,9) Details
ATPase 283(2,5,6,28) Details
acetylcholine receptors (protein family or complex) 247(2,4,6,17) Details
CS2 229(2,4,4,9) Details
5HT transporter 165(2,2,2,5) Details
choline acetyltransferase 118(1,2,2,8) Details
cytochrome c 116(1,2,2,6) Details
SRBC 112(1,2,2,2) Details
lactate dehydrogenase (protein family or complex) 100(1,1,3,10) Details
malate dehydrogenase 88(1,1,2,3) Details
succinate dehydrogenase (protein family or complex) 88(1,1,2,3) Details
CYP2B 85(1,1,1,5) Details
NADPH cytochrome P450 reductase 83(1,1,1,3) Details
tumor necrosis factor alpha 82(1,1,1,2) Details
adiponectin 82(1,1,1,2) Details
XL1 82(1,1,1,2) Details
interleukin 2 82(1,1,1,2) Details
malate dehydrogenase mitochondrial 81(1,1,1,1) Details
IL 5 81(1,1,1,1) Details
cytochrome P450 2D6 106(0,3,4,11) Details
brains 80(0,2,3,15) Details
carbonic anhydrase 79(0,2,4,9) Details
calmodulin 77(0,2,4,7) Details
microsomal monooxygenases 70(0,2,2,10) Details
glutathione transferase 65(0,2,2,5) Details
aspartate aminotransferase 46(0,1,3,6) Details
transferase 43(0,1,1,13) Details
Glutamate pyruvate transaminase 41(0,1,2,6) Details
neurotrophins 41(0,1,2,6) Details
CYP1A2 38(0,1,1,8) Details
apoprotein 34(0,1,1,4) Details
PN1 34(0,1,1,4) Details
G proteins 34(0,1,1,4) Details
CYP2C9 33(0,1,1,3) Details
B15 32(0,1,1,2) Details
PCNA 32(0,1,1,2) Details
choline transporter 32(0,1,1,2) Details
Nerve growth factor 32(0,1,1,2) Details
chitinase 31(0,1,1,1) Details
PCCA 31(0,1,1,1) Details
nNOS 31(0,1,1,1) Details
caspase 8 31(0,1,1,1) Details
interferon (protein family or complex) 31(0,1,1,1) Details
ATPases 41(0,0,6,11) Details
alkaline phosphatase 34(0,0,3,19) Details
muscles 28(0,0,1,23) Details
hexose 6 phosphate dehydrogenase 24(0,0,3,9) Details
N acetyltransferase 19(0,0,3,4) Details
SERS 18(0,0,3,3) Details
acid phosphatase 18(0,0,2,8) Details
C18 18(0,0,1,13) Details
Ha ras 15(0,0,2,5) Details
HC5 15(0,0,2,5) Details
protein is 15(0,0,2,5) Details
metallothionein (protein family or complex) 14(0,0,2,4) Details
CYP3A7 13(0,0,2,3) Details
F11 13(0,0,2,3) Details
hemoglobin (protein family or complex) 13(0,0,1,8) Details
sulfotransferases (protein family or complex) 13(0,0,2,3) Details
EGFR 12(0,0,2,2) Details
MGST1 12(0,0,2,2) Details
rac 3 12(0,0,2,2) Details
hydroxyindole O methyltransferase 12(0,0,2,2) Details
TPMT 12(0,0,2,2) Details
CYP2F1 12(0,0,2,2) Details
beta catenin 12(0,0,2,2) Details
c kit 12(0,0,2,2) Details
CYP4F3 12(0,0,2,2) Details
catalase 11(0,0,1,6) Details
superoxide dismutase 10(0,0,1,5) Details
CARB 9(0,0,1,4) Details
neurotoxic esterase 9(0,0,0,9) Details
lipase 8(0,0,0,8) Details
GSTP1 1 8(0,0,1,3) Details
annexin V 7(0,0,1,2) Details
uroporphyrinogen decarboxylase 7(0,0,0,7) Details
complex is 7(0,0,1,2) Details
glutathione reductase 7(0,0,1,2) Details
Cytochrome c oxidase (protein family or complex) 7(0,0,1,2) Details
MCM2 7(0,0,1,2) Details
beta glucuronidase 7(0,0,0,7) Details
beta hexosaminidase 7(0,0,1,2) Details
demethylase 7(0,0,0,7) Details
TEPP 7(0,0,1,2) Details
MMS 6(0,0,1,1) Details
CF1 6(0,0,1,1) Details
MPE 6(0,0,1,1) Details
CD146 6(0,0,1,1) Details
p43 6(0,0,1,1) Details
UGT2B 6(0,0,1,1) Details
Ezrin 6(0,0,1,1) Details
glycosyltransferases 6(0,0,1,1) Details
Notch 4 6(0,0,1,1) Details
MT1X 6(0,0,1,1) Details
GSTT2 6(0,0,1,1) Details
CHST6 6(0,0,1,1) Details
CHST7 6(0,0,1,1) Details
cholesterol acyltransferase 6(0,0,1,1) Details
CHST5 6(0,0,1,1) Details
Dvl 2 6(0,0,1,1) Details
TP53 6(0,0,1,1) Details
xanthine oxidase 6(0,0,1,1) Details
CYP2E1 6(0,0,0,6) Details
DVL1 6(0,0,1,1) Details
Anas 6(0,0,1,1) Details
progestins (protein family or complex) 6(0,0,1,1) Details
caspase (protein family or complex) 6(0,0,0,6) Details
Substance P 6(0,0,0,6) Details
UGT1A1 6(0,0,1,1) Details
G protein coupled receptor kinase 2 5(0,0,0,5) Details
follicle stimulating hormone (protein family or complex) 5(0,0,0,5) Details
P glycoprotein 5(0,0,0,5) Details
estrogen receptor 5(0,0,0,5) Details
hsp70 1 4(0,0,0,4) Details
GSTA4 4 4(0,0,0,4) Details
Koc 3(0,0,0,3) Details
DCIP 3(0,0,0,3) Details
SULT2A1 3(0,0,0,3) Details
Salvador 3(0,0,0,3) Details
ScFv 3(0,0,0,3) Details
protein kinase C (protein family or complex) 3(0,0,0,3) Details
Tyrosinase 3(0,0,0,3) Details
CYP2C19 3(0,0,0,3) Details
CYP2B6 3(0,0,0,3) Details
SULT1A1 3(0,0,0,3) Details
glutamyl transpeptidase 2(0,0,0,2) Details
phosphodiesterase 2(0,0,0,2) Details
Hsp70 2(0,0,0,2) Details
S100beta 2(0,0,0,2) Details
CYP1A1 2(0,0,0,2) Details
immunoglobulin (protein family or complex) 2(0,0,0,2) Details
caspase 9 2(0,0,0,2) Details
glutamine synthetase 2(0,0,0,2) Details
CYP3A5 2(0,0,0,2) Details
GSTT1 2(0,0,0,2) Details
glial fibrillary acidic protein 2(0,0,0,2) Details
c reactive protein 2(0,0,0,2) Details
thyroid stimulating hormone (protein family or complex) 2(0,0,0,2) Details
B27 2(0,0,0,2) Details
cathepsin B 2(0,0,0,2) Details
lipoprotein lipase 2(0,0,0,2) Details
androgen receptor 2(0,0,0,2) Details
CD25 2(0,0,0,2) Details
P230 2(0,0,0,2) Details
apoA I 2(0,0,0,2) Details
CA4 2(0,0,0,2) Details
glucagon receptors 2(0,0,0,2) Details
SLAM 2(0,0,0,2) Details
POLE 2(0,0,0,2) Details
SPRC 2(0,0,0,2) Details
CD69 2(0,0,0,2) Details
cyclin dependent kinases (protein family or complex) 2(0,0,0,2) Details
lambda 5 2(0,0,0,2) Details
IGFBP5 1(0,0,0,1) Details
nestin 1(0,0,0,1) Details
AE1 1(0,0,0,1) Details
apolipoproteins 1(0,0,0,1) Details
palmitoyl CoA oxidase 1(0,0,0,1) Details
HP 1 1(0,0,0,1) Details
OASIS 1(0,0,0,1) Details
ATPase is 1(0,0,0,1) Details
caspase 7 1(0,0,0,1) Details
SIDS 1(0,0,0,1) Details
cyclin D3 1(0,0,0,1) Details
glutamic acid decarboxylase 1(0,0,0,1) Details
MT1A 1(0,0,0,1) Details
MDM2 1(0,0,0,1) Details
CYP1B1 1(0,0,0,1) Details
G protein coupled receptors 1(0,0,0,1) Details
got 2 1(0,0,0,1) Details
CYP2 1(0,0,0,1) Details
CMAP 1(0,0,0,1) Details
AOX1 1(0,0,0,1) Details
GSTA3 3 1(0,0,0,1) Details
protein B 1(0,0,0,1) Details
PON2 1(0,0,0,1) Details
fizzy related protein 1(0,0,0,1) Details
MT1L 1(0,0,0,1) Details
p45 1(0,0,0,1) Details
PON3 1(0,0,0,1) Details
cyclin dependent kinase 4 1(0,0,0,1) Details
MM1 1(0,0,0,1) Details
aldolase B 1(0,0,0,1) Details
Pth 1 1(0,0,0,1) Details
IGFBP3 1(0,0,0,1) Details
MT1H 1(0,0,0,1) Details
lecithin cholesterol acyltransferase 1(0,0,0,1) Details
AKR1C1 1(0,0,0,1) Details
p32 1(0,0,0,1) Details
mitochondrial ATPases 1(0,0,0,1) Details
hepatic lipase 1(0,0,0,1) Details
MT1E 1(0,0,0,1) Details
alpha ii 1(0,0,0,1) Details
serine protease inhibitor 1(0,0,0,1) Details
NF E2 1(0,0,0,1) Details
phosphotriesterase related 1(0,0,0,1) Details
GSTA5 1(0,0,0,1) Details
MCM3 1(0,0,0,1) Details
MT2A 1(0,0,0,1) Details
GSHS 1(0,0,0,1) Details
isocitrate dehydrogenase 1(0,0,0,1) Details
clusterin 1(0,0,0,1) Details
sodium channel (protein family or complex) 1(0,0,0,1) Details
adenylate cyclase 1(0,0,0,1) Details
NMDA receptor (protein family or complex) 1(0,0,0,1) Details
c fos 1(0,0,0,1) Details
arginase 1(0,0,0,1) Details
CYP19 1(0,0,0,1) Details
glutaminase 1(0,0,0,1) Details
monoamine oxidase 1(0,0,0,1) Details
CF 1 (protein family or complex) 1(0,0,0,1) Details
myelin basic protein 1(0,0,0,1) Details
liver carboxylesterase 1(0,0,0,1) Details
plasminogen 1(0,0,0,1) Details
ace 1 1(0,0,0,1) Details
esterase B3 1(0,0,0,1) Details
per 1 1(0,0,0,1) Details
casein 1(0,0,0,1) Details
cytochrome P450 monooxygenase 1(0,0,0,1) Details
protein as 1(0,0,0,1) Details
alpha tubulin 1(0,0,0,1) Details
adenosine A1 receptor 1(0,0,0,1) Details
NK1 1(0,0,0,1) Details
glucagon 1(0,0,0,1) Details
aryl hydrocarbon receptor 1(0,0,0,1) Details
pg m 1(0,0,0,1) Details
Cl 2 1(0,0,0,1) Details
sulfotransferase 1(0,0,0,1) Details
neurofilament protein 1(0,0,0,1) Details
tyrosine aminotransferase 1(0,0,0,1) Details
GSTM1 1(0,0,0,1) Details
DTNB 1(0,0,0,1) Details
CYP2C18 1(0,0,0,1) Details
heme oxygenase 1 1(0,0,0,1) Details
alkaline phosphatases 1(0,0,0,1) Details
pyruvate dehydrogenase (protein family or complex) 1(0,0,0,1) Details
Protein S 1(0,0,0,1) Details
beta glucosidase 1(0,0,0,1) Details
keratin (protein family or complex) 1(0,0,0,1) Details
SP2 1(0,0,0,1) Details
SP A 1(0,0,0,1) Details
thrombin 1(0,0,0,1) Details
aldolase A 1(0,0,0,1) Details
aldo keto reductase (protein family or complex) 1(0,0,0,1) Details
OV 1 1(0,0,0,1) Details
progesterone receptor 1(0,0,0,1) Details
keratin 18 1(0,0,0,1) Details
epidermal growth factor 1(0,0,0,1) Details
Carboxypeptidase (protein family or complex) 1(0,0,0,1) Details
P21 1(0,0,0,1) Details
granulocyte colony stimulating factor 1(0,0,0,1) Details
CSFR 1(0,0,0,1) Details
CD18 1(0,0,0,1) Details
protein tyrosine phosphatase 1(0,0,0,1) Details
CD14 1(0,0,0,1) Details
cyclin D1 1(0,0,0,1) Details
signal peptidase (protein family or complex) 1(0,0,0,1) Details
O acetyltransferase 1(0,0,0,1) Details
leucine aminopeptidase 1(0,0,0,1) Details
SN2 1(0,0,0,1) Details
MBP (protein family or complex) 1(0,0,0,1) Details
Ki 67 1(0,0,0,1) Details
iceberg 1(0,0,0,1) Details
MM2 1(0,0,0,1) Details
glutamate receptors (protein family or complex) 0(0,0,0,0) Details
p47phox 0(0,0,0,0) Details
granulocyte colony stimulating factor receptor 0(0,0,0,0) Details
interleukin (protein family or complex) 0(0,0,0,0) Details
MAGE (protein family or complex) 0(0,0,0,0) Details
p67phox 0(0,0,0,0) Details
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