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El-Sebae AH, Enan EE, Soliman SA, El-Fiki S, Khamees E: Biochemical effects of some organophosphorus insecticide on new targets in white rats. J Environ Sci Health B. 1981;16(4):475-91.
The three S-n-propyl phosphates and phosphothioates: RH 218, profenofos and prothiophos were compared with fenitrothion in their potential as inhibitors of rat liver and brain AChE. Fenitrothion was more potent as an inhibitor than the three S-n-propyl derivatives. Incubation of hepatic protein enhanced ChE inhibition in brain in the case of fenitrothion, while it reduced the inhibitory effect of the S-n-propyl derivatives. On the other hand, the four organophosphorus esters caused hypoglycemia in both male and female rats and also reduced their blood urea with different degrees. |
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