| 14650183 |
Lin L, Liu J, Zhang K, Chen Y: [An experimental study of the effects of profenofos on antioxidase in rabbits]. Wei Sheng Yan Jiu. 2003 Sep;32(5):434-5.
In order to explore the effects of superoxide dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px) in rabbits exposed by profenofos and its meaning. 18 rabbits were divided into three groups randomly: A group (high-dose group), B group (low-dose group), C group (control group), each group including 6 rabbits. The activities of SOD, CAT, GSH-Px in plasma, and cholinesterase (ChE) in blood were measured in different exposure period. The results showed that activities of SOD, CAT and GSH-Px increased, ChE decreased markedly compared with those in the same group before experiment and control group (P < 0.05, P < 0.01). The increase of antioxidase activities was earlier than the decease of ChE activity. It suggests that profenofos can result in the increases of the activities of SOD, CAT and GSH-Px, which may be earlier diagnostic index in profenofos poisoning. |
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