| 18066900 |
Broggi J, Joubert N, Aucagne V, Zevaco T, Berteina-Raboin S, Nolan SP, Agrofoglio LA: Study of different copper (I) catalysts for the "click chemistry" approach to carbanucleosides. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):779-83.
We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis (acetonitrile) copper hexafluorophosphate ([Cu (CH3CN) 4] PF6), the imidazoline (mesythyl) copper bromide (Imes) CuBr, and the copper/copper sulfate Cu (0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method. |
6(0,0,1,1) |