| 7807141 |
Rodriguez-Ithurralde D, Vincent O: Excitotoxicity and cholinergic chemical markers during programmed motor neurone death. J Neurol Sci. 1994 Jul;124 Suppl:52-3.
We measured cholinergic markers and acetylcholinesterase (AChE) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. AChE globular forms were secreted in a dose-dependent fashion. A period of selective sensitivity to excitotoxic agents was detected by increased acetylcholine (ACh) release and AChE secretion (sAChE) at postnatal day 14. Strychnine-resistant glycine stimulation potentiated glutamate-induced AChE release, suggesting N-methyl-D-aspartate (NMDA) receptor involvement. |
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