| 19949270 |
Amizuka N, Li M, Guo Y, Liu Z, Suzuki R, Yamamoto T: [Biological effects of vitamin K2 on bone quality] . Clin Calcium. 2009 Dec;19(12):1788-96.
Post-transcriptional maturation with the presence of vitamin K (2) promotes gamma-carboxylation of osteocalcin, enabling further binding to hydroxyapatite, from which one could infer that vitamin K (2) increased the quality of bone matrix. For instance, vitamin K (2) rescued the impaired collagen mineralization caused by Mg insufficiency, by promoting a re-association of the process of collagen mineralization with mineralized nodules. Sodium warfarin, which antagonizes the function of vitamin K (2), reduced the binding of osteocalcin to bone matrices, and consequently resulted in crystalline particles being dispersed throughout the osteoid without forming mineralized nodules. Therefore, gamma-carboxylated Gla proteins mediated by vitamin K (2) appear to play a pivotal role in normal mineralization in bone. |
82(1,1,1,2) |