| 7947941 |
Brandsma AE, Tibboel D, Vulto IM, de Vijlder JJ, Ten Have-Opbroek AA, Wiersinga WM: Inhibition of T3-receptor binding by Nitrofen. . Biochim Biophys Acta. 1994 Nov 11;1201(2):266-70.
Lung development is controlled by various hormones, including thyroid hormone. The herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) induces lung hypoplasia in fetal rats, when administered to the mother during gestation. Nitrofen might be teratogenic by an anti-thyroid activity. The present study shows that Nitrofen decreases the binding of T3 to the alpha 1 and beta 1 form of the thyroid hormone receptor in a non-competitive way. Consequently, rat lung hypoplasia might result from the decreased binding of T3 to its receptor, via exposure to Nitrofen during fetal development. |
81(1,1,1,1) |