| ID | 21 |
|---|---|
| Name | chloride channel (protein family or complex) |
| Synonyms | chloride channel |
| ID | 182 |
|---|---|
| Name | endosulfan |
| CAS | 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin 3-oxide |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 8546445 | Bloomquist JR: Ion channels as targets for insecticides. Annu Rev Entomol. 1996;41:163-90. Ion channels are the primary target sites for several classes of natural and synthetic insecticidal compounds. The voltage-sensitive sodium channel is the major target site for DDT and pyrethroids, the veratrum alkaloids, and N-alkylamides. Recently, proteins from arthropod venoms, some of which specifically attack insect channels, have been engineered into baculoviruses to act as biopesticides. The synthetic pyrazolines also primarily affect the sodium channel, although some members of this group target neuronal channels as well. The ryanoids have also found use as insecticides, and these materials induce muscle contracture by irreversible activation of the -release channel of the sarcoplasmic reticulum. The arylheterocycles (e.g. endosulfan and fipronil) are potent convulsants and insecticides that block the -gated chloride channel. In contrast, the avermectins activate both ligand- and voltage-gated channels, which leads to paralysis. At field-use rates, a effect of the ecdysteroid agonist RH-5849 is observed that involves blockage of both muscle and neuronal channels. The future use of ion channels as targets for chemical and genetically engineered insecticides is also discussed. |
81(1,1,1,1) |