progesterone receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term progesterone receptor
UniProt ID PRGR_RAT
Name Progesterone receptor
Nuclear receptor subfamily 3 group C member 3
PR
Gene Names Pgr
Synonyms:Nr3c3
Taxonomy Rattus norvegicus

General annotation

Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform is involved in activation of c-SRC/MAPK signaling on hormone stimulation (By similarity).
Subcellular location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases (By similarity).

Gene Ontology

GO:0042562 hormone binding MF
GO:0001553 luteinization BP
GO:0016101 diterpenoid metabolic process BP
GO:0005634 nucleus CC
GO:0043005 neuron projection CC
GO:0005496 steroid binding MF
GO:0003707 steroid hormone receptor activity MF
GO:0045892 negative regulation of transcription, DNA-dependent BP
GO:0045893 positive regulation of transcription, DNA-dependent BP
GO:0043565 sequence-specific DNA binding MF
GO:0071373 cellular response to luteinizing hormone stimulus BP
GO:0005829 cytosol CC
GO:0008270 zinc ion binding MF
GO:0006351 transcription, DNA-dependent BP
GO:0071372 cellular response to follicle-stimulating hormone stimulus BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF

Sequence

>gi|12408292|ref|NP_074038.1| progesterone receptor [Rattus norvegicus]
MTELQAKDPRTLHTSGAAPSPTHVGSPLLARLDPDPFQGSQHSDASSVVSPIPISLDRLLFSRSCQAQEL
PDEKTQNQQSLSDVEGAFSGVEASRRRSRNPRAPEKDSRLLDSVLDTLLAPSGPEQSQTSPPACEAITSW
CLFGPELPEDPRSVPATKGLLSPLMSRPESKAGDSSGTGAGQKVLPKAVSPPRQLLLPTSGSAHWPGAGV
KPSQQPATVEVEEDGGLETEGSAGPLLKSKPRALEGMCSGGGVTANAPGAAPGGVTLVPKEDSRFSAPRV
SLEQDAPVAPGRSPLATTVVDFIHVPILPLNHALLAARTRQLLEGDSYDGGAAAQVPFAPPRGSPSAPSP
PVPCGDFPDCTYPPEGDPKEDGFPVYGEFQPPGLKIKEEEEGTEAASRSPRPYLLAGASAATFPDFPLPP
RPPRAPPSRPGEAAVAAPSAAVSPVSSSGSALECILYKAEGAPPTQGSFAPLPCKPPAASSCLLPRDSLP
AAPTSSAAPAIYPPLGLNGLPQLGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSPQYGFDSLPQKICLIC
GDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFK
KFNKVRVMRALDGVALPQSVAFPNESQTLGQRITFSPNQEIQLVPPLINLLMSIEPDVVYAGHDNTKPDT
SSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKELSFYSLCLTMWQIPQEFVKLQVTHEEFLCMKVLLLLNTIPLEGLRSQSQFEEMRSSYIR
ELIKAIGLRQKGVVPSSQRFYQLTKLLDSLHDLVKQLHLYCLNTFIQSRALAVEFPEMMSEVIAAQLPKI
LAGMVKPLLFHKK

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Database Cross Reference

Ensembl Gene
UniGene Rn.10303
PDB
RefSeq NP_074038.1
Pfam PF00105
PF02161
PF00104