serine racemase

General Information (Source: NCBI Gene,UniProt)

Text mining Term serine racemase
UniProt ID SRR_MOUSE
Name D-serine dehydratase
Serine racemase
L-serine dehydratase
D-serine ammonia-lyase
L-serine ammonia-lyase
Gene Names Srr
Taxonomy Mus musculus

General annotation

Function Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Subcellular location

Gene Ontology

GO:0003941 L-serine ammonia-lyase activity MF
GO:0008721 D-serine ammonia-lyase activity MF
GO:0005524 ATP binding MF
GO:0070179 D-serine biosynthetic process BP
GO:0030378 serine racemase activity MF
GO:0051289 protein homotetramerization BP
GO:0042803 protein homodimerization activity MF
GO:0006563 L-serine metabolic process BP
GO:0018114 threonine racemase activity MF
GO:0016594 glycine binding MF
GO:0005509 calcium ion binding MF
GO:0030170 pyridoxal phosphate binding MF

Sequence

>gi|254028195|ref|NP_001156783.1| serine racemase [Mus musculus]
MCAQYCISFADVEKAHINIQDSIHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPD
TPEEKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYCDPSDESREKVTQ
RIMQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKALKPSVKVYAAE
PSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWGRMKL
LIEPTAGVALAAVLSQHFQTVSPEVKNVCIVLSGGNVDLTSLNWVGQAERPAPYQTVSV

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Database Cross Reference

Ensembl Gene ENSMUST00000108447
ENSMUST00000108448
ENSMUST00000071240
ENSMUST00000121738
ENSMUST00000128556
ENSMUST00000065211
ENSMUST00000123855
UniGene Mm.220843
Mm.412219
Mm.131443
PDB
RefSeq NP_038789.1
NP_001156783.1
Pfam PF00291