multidrug resistance associated protein 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term multidrug resistance associated protein 1
UniProt ID MRP1_RAT
Name Leukotriene C(4) transporter
ATP-binding cassette sub-family C member 1
Multidrug resistance-associated protein 1
LTC4 transporter
Gene Names Abcc1
Synonyms:Mrp1
Taxonomy Rattus norvegicus

General annotation

Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Subcellular location Cell membrane; Multi-pass membrane protein.

Gene Ontology

GO:0016491 oxidoreductase activity MF
GO:0043526 neuroprotection BP
GO:0034040 lipid-transporting ATPase activity MF
GO:0015431 glutathione S-conjugate-exporting ATPase activity MF
GO:0005524 ATP binding MF
GO:0033700 phospholipid efflux BP
GO:0046618 drug export BP
GO:0005887 integral to plasma membrane CC
GO:0008559 xenobiotic-transporting ATPase activity MF
GO:0006979 response to oxidative stress BP
GO:0005737 cytoplasm CC
GO:0016323 basolateral plasma membrane CC
GO:0046624 sphingolipid transporter activity MF
GO:0005324 long-chain fatty acid transporter activity MF
GO:0030335 positive regulation of cell migration BP
GO:0015911 plasma membrane long-chain fatty acid transport BP
GO:0060326 cell chemotaxis BP
GO:0015562 efflux transmembrane transporter activity MF
GO:0043215 daunorubicin transport BP
GO:0034634 glutathione transmembrane transporter activity MF

Sequence

>gi|31542029|ref|NP_071617.2| multidrug resistance-associated protein 1 [Rattus norvegicus]
MALSSFCSSDGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFLYLSRHDRGYIQMTHL
NKAKTALGFFLWIICWADLFYSFWERSQGMLLAPVLLVSPTLLGITMLLATFLIQFERRKGVQSSGIMLT
FWLVALLCALAILRSKIISALKKDAQVDMFRDSAFYLYFTLVFIQLVLSCFSDSSPLFSETVRDPNPCPE
SSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPP
KDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELI
INFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSST
VGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKT
YQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFL
VALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDS
IERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVE
GHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLS
GGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVII
VMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGLGKESKPVENGILVTDAVGKP
LQRHLSNSSSHSVVTNQQHSSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIF
LFLCNHVSALASNYWLSLWTDDRPAVNGTQENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLH
LDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVII
PPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAY
YPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIV
AVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRT
GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV
WMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQ
STIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAKDAGLV

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Database Cross Reference

Ensembl Gene
UniGene Rn.10495
PDB
RefSeq NP_071617.2
Pfam PF00664
PF00005