Beclin 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term Beclin 1
UniProt ID BECN1_MOUSE
Name Coiled-coil myosin-like BCL2-interacting protein
Beclin-1
Gene Names Becn1
Taxonomy Mus musculus

General annotation

Function Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense.
Subcellular location Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity). Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Gene Ontology

GO:0016239 positive regulation of macroautophagy BP
GO:0009615 response to virus BP
GO:0008285 negative regulation of cell proliferation BP
GO:0005802 trans-Golgi network CC
GO:0016023 cytoplasmic membrane-bounded vesicle CC
GO:0005515 protein binding MF
GO:0016020 membrane CC
GO:0043234 protein complex CC
GO:0007049 cell cycle BP
GO:0000910 cytokinesis BP

Sequence

>gi|27764875|ref|NP_062530.2| beclin-1 [Mus musculus]
MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEEANSGEEPFIE
TRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTD
TLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENL
EKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATFHIWHSGQF
GTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLY
CSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSE
EQWTKALKFMLTNLKWGLAWVSSQFYNK

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Database Cross Reference

Ensembl Gene ENSMUST00000130916
UniGene Mm.178947
PDB 3BL2
RefSeq NP_062530.2
Pfam PF04111