Beclin 1

General Information (Source: NCBI Gene,UniProt)

Text mining Term Beclin 1
UniProt ID BECN1_RAT
Name Coiled-coil myosin-like BCL2-interacting protein
Protein GT197
Beclin-1
Gene Names Becn1
Taxonomy Rattus norvegicus

General annotation

Function Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense (By similarity).
Subcellular location Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein (By similarity). Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity).

Gene Ontology

GO:0016020 membrane CC
GO:0000910 cytokinesis BP
GO:0007049 cell cycle BP
GO:0000045 autophagic vacuole assembly BP
GO:0009615 response to virus BP

Sequence

>gi|16758562|ref|NP_446191.1| beclin-1 [Rattus norvegicus]
MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGESQEEEANSGEEPFIE
TRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTD
TLLDQLDTQLNVTENECQNYKRCLEMLEQMNEGDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENL
EKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATFHIWHSGQF
GTINNFRLGRLPSAPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLY
CSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSE
EQWTKALKFMLTNLKWGLAWVSSQFYNK

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000027868
UniGene Rn.2776
PDB
RefSeq NP_001029289.1
NP_446191.1
Pfam PF04111