osteocalcin

General Information (Source: NCBI Gene,UniProt)

Text mining Term osteocalcin
UniProt ID OSTCN_RAT
Name Osteocalcin
Gamma-carboxyglutamic acid-containing protein
BGP
Bone Gla protein
Gene Names Bglap
Synonyms:Bglap2
Taxonomy Rattus norvegicus

General annotation

Function Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Subcellular location Secreted.

Gene Ontology

GO:0033594 response to hydroxyisoflavone BP
GO:0071363 cellular response to growth factor stimulus BP
GO:0060348 bone development BP
GO:0002076 osteoblast development BP
GO:0009612 response to mechanical stimulus BP
GO:0005794 Golgi apparatus CC
GO:0045471 response to ethanol BP
GO:0005615 extracellular space CC
GO:0005791 rough endoplasmic reticulum CC
GO:0042995 cell projection CC
GO:0033574 response to testosterone stimulus BP
GO:0042493 response to drug BP
GO:0030500 regulation of bone mineralization BP
GO:0010043 response to zinc ion BP
GO:0051384 response to glucocorticoid stimulus BP
GO:0071305 cellular response to vitamin D BP
GO:0009629 response to gravity BP
GO:0007569 cell aging BP
GO:0043627 response to estrogen stimulus BP
GO:0031988 membrane-bounded vesicle CC
GO:0014823 response to activity BP
GO:0031214 biomineral tissue development BP
GO:0005509 calcium ion binding MF
GO:0042476 odontogenesis BP
GO:0008147 structural constituent of bone MF

Sequence

>gi|11761543|ref|NP_038200.1| osteocalcin preproprotein [Rattus norvegicus]
MRTLSLLTLLALTAFCLSDLAGAKPSDSESDKAFMSKQEGSKVVNRLRRYLNNGLGAPAPYPDPLEPHRE
VCELNPNCDELADHIGFQDAYKRIYGTTV

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000026530
UniGene Rn.9722
PDB
RefSeq NP_038200.1
Pfam PF00594