prostaglandin D2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term prostaglandin D2 receptor
UniProt ID PD2R_MOUSE
Name PGD receptor
PGD2 receptor
Prostanoid DP receptor
Prostaglandin D2 receptor
Gene Names Ptgdr
Taxonomy Mus musculus

General annotation

Function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Subcellular location Cell membrane; Multi-pass membrane protein (Potential).

Gene Ontology

GO:0046085 adenosine metabolic process BP
GO:0030431 sleep BP
GO:0071799 cellular response to prostaglandin D stimulus BP
GO:0001785 prostaglandin J receptor activity MF
GO:0005886 plasma membrane CC
GO:0030238 male sex determination BP
GO:0016021 integral to membrane CC
GO:0004956 prostaglandin D receptor activity MF

Sequence

>gi|225543126|ref|NP_032988.3| prostaglandin D2 receptor [Mus musculus]
MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVT
DLLGKCLISPMVLAAYAQNQSLKELLPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFFYQ
RHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQMIHKERSFSVIGFSVLYSSLMALLV
LATVVCNLGAMYNLYDMHRRQRHYPHRCSRDRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMCSLPL
IYRAYYGAFKLENKAEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQQ
SNVESTL

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Database Cross Reference

Ensembl Gene ENSMUST00000095959
UniGene Mm.5105
PDB
RefSeq NP_032988.3
Pfam PF00001