prostaglandin D2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term prostaglandin D2 receptor
UniProt ID PD2R_RAT
Name PGD2 receptor
PGD receptor
Prostanoid DP receptor
Prostaglandin D2 receptor
Gene Names Ptgdr
Taxonomy Rattus norvegicus

General annotation

Function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.
Subcellular location Cell membrane; Multi-pass membrane protein (Potential).

Gene Ontology

GO:0005886 plasma membrane CC
GO:0016021 integral to membrane CC
GO:0004956 prostaglandin D receptor activity MF

Sequence

>gi|206597432|ref|NP_001128636.1| prostaglandin D2 receptor [Rattus norvegicus]
MNESYRCQAATWVERGSSATMGGVAFSAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVT
DLLGKCLISPMVLAAYAQNRSLKELLPASGNQLCEAFAFLMSFFGLASTLQLLAMALECWLSLGHPFFYQ
RHITARRGVLVAPVAGAFSLAFCALPFAGFGKFVQYCPGTWCFIQMIHKKRSFSVIGFSVLYSSLMALLV
LATVVCNLGAMSNLYAMHRRQRHHPRRCSRDRAQSGSDYRHGSPNPLEELDHFVLLALTTVLFTMCSLPL
IYRAYYGAFKLVDRADGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKTFTRPLIYRNWCSHSWQ
TNMESTL

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Database Cross Reference

Ensembl Gene
UniGene Rn.57393
PDB
RefSeq NP_001128636.1
Pfam PF00001