prostaglandin D2 receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term prostaglandin D2 receptor
UniProt ID PD2RL_RAT
Name Prostanoid DP receptor-like
PGD receptor-like
Prostaglandin D2 receptor-like
PGD2 receptor-like
Gene Names Ptgdrl
Synonyms:Ptgdr2
Taxonomy Rattus norvegicus

General annotation

Function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Subcellular location Cell membrane; Multi-pass membrane protein (Potential).

Gene Ontology

GO:0005829 cytosol CC
GO:0005624 membrane fraction CC
GO:0016021 integral to membrane CC
GO:0005886 plasma membrane CC
GO:0004956 prostaglandin D receptor activity MF
GO:0060406 positive regulation of penile erection BP
GO:0051480 cytosolic calcium ion homeostasis BP
GO:0045909 positive regulation of vasodilation BP

Sequence

>gi|11560040|ref|NP_071577.1| prostaglandin D2 receptor-like [Rattus norvegicus]
MNESYRCQAATWVERGSSATMGGVLFSAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVT
HLLGKCLISPMVLAAYAQNRSLKELLPASGNQLCEAFAFLMSFFGLASTLQLLAMALECWLSLGHPFFYQ
RHITARRGVLVAPVAGAFSLAFCALPFAGFGKFVQYCPGTWCFIQMIHKKRSFSVIGFSVLYSSLMALLV
LATVVCNLGAMSNLYAMHRRQRHHPRRCSRDRAQSGSDYRHGSPNPLEELDHFVLLALTTVLFTMCSLPL
IYRAYYGAFKLVDRADGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKAFTRPLIYRNWCSHSWQ
TNMESTL

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Database Cross Reference

Ensembl Gene
UniGene Rn.110861
PDB
RefSeq NP_071577.1
Pfam PF00001