myelin basic protein

General Information (Source: NCBI Gene,UniProt)

Text mining Term myelin basic protein
UniProt ID MBP_RAT
Name MBP S
Myelin basic protein S
Gene Names Mbp
Taxonomy Rattus norvegicus

General annotation

Function Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
Subcellular location Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.

Gene Ontology

GO:0005886 plasma membrane CC
GO:0050771 negative regulation of axonogenesis BP
GO:0019911 structural constituent of myelin sheath MF
GO:0005515 protein binding MF
GO:0043218 compact myelin CC
GO:0042552 myelination BP

Sequence

>gi|70166262|ref|NP_001020464.1| myelin basic protein isoform 3 [Rattus norvegicus]
MASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKVPWLKQSRSPL
PSHARSRPGLCHMYKDSHTRTTHYGSLPQKSQRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSW
GGRDSRSGSPMARR

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000022303
UniGene Rn.63285
PDB
RefSeq NP_001020465.1
NP_058722.1
NP_001020464.1
NP_001020462.1
NP_001020463.1
Pfam PF01669