aryl hydrocarbon receptor

General Information (Source: NCBI Gene,UniProt)

Text mining Term aryl hydrocarbon receptor
UniProt ID AHR_RAT
Name Aryl hydrocarbon receptor
AhR
Ah receptor
Gene Names Ahr
Taxonomy Rattus norvegicus

General annotation

Function Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.
Subcellular location Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Gene Ontology

GO:0009410 response to xenobiotic stimulus BP
GO:0005634 nucleus CC
GO:0006950 response to stress BP
GO:0007049 cell cycle BP
GO:0004879 ligand-dependent nuclear receptor activity MF
GO:0006366 transcription from RNA polymerase II promoter BP
GO:0001541 ovarian follicle development BP
GO:0071385 cellular response to glucocorticoid stimulus BP
GO:0006915 apoptotic process BP
GO:0014070 response to organic cyclic compound BP
GO:0003700 sequence-specific DNA binding transcription factor activity MF
GO:0004874 aryl hydrocarbon receptor activity MF
GO:0005829 cytosol CC
GO:0032355 response to estradiol stimulus BP

Sequence

>gi|145207984|ref|NP_037281.2| aryl hydrocarbon receptor precursor [Rattus norvegicus]
MSSGANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLR
LSVTYLRAKSFFDVALKSTPADRSRGQDQCRAQVRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTI
QDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTDSAQGVDETHGLPQPAVYYTPDQLPPEN
TAFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRT
KNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCNKGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFR
LLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSMTLPFMFATGEAVLYEISSPFSP
IMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPNSLMSALIQQDESIYLCPPSSPAPLDSHFLMDSMSECGS
WQGSFAVASNEALLKHEEIRHTQDVNLTLSGGPSELFPDNKNNDLYSIMRNLGIDFEDIRSMQNEEFFRT
DSSGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVSQHLSCMLQERLQLEQQQQLQQQHPTQTLE
PQRQLCQVEVPQHELGQKTKHMQVNGMFVSWNPAPPVSFSCPQQERKHICLLSGLQGTAQEFPYKSEVDS
MPYTQNFAPCNQSLLPEHSKGTQLDFPGRDFERSLHPNVSNLEEFVSCLQVPENQRHGINSQSAMVSPQG
YYAGAMSMYQCQAGPQDTPVDQMQYSPEIPGSQAFLSKFQSPSILNEAYSADLSSIGHLQTAAHLPRLAE
AQPLPDITPSGFL

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Rn.91370
PDB
RefSeq NP_037281.2
Pfam PF00989
PF08447
PF00010