Connexin 43

General Information (Source: NCBI Gene,UniProt)

Text mining Term Connexin 43
UniProt ID Q544I7_MOUSE
Name Gap junction protein
Gene Names Gja1
Synonyms:Npm1
Taxonomy Mus musculus

General annotation

Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity).
Subcellular location Membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0001764 neuron migration BP
GO:0016021 integral to membrane CC
GO:0005243 gap junction channel activity MF
GO:0001701 in utero embryonic development BP
GO:0002070 epithelial cell maturation BP
GO:0043403 skeletal muscle tissue regeneration BP
GO:0010628 positive regulation of gene expression BP
GO:0010629 negative regulation of gene expression BP
GO:0007512 adult heart development BP
GO:0008016 regulation of heart contraction BP
GO:0005916 fascia adherens CC
GO:0006915 apoptotic process BP
GO:0001947 heart looping BP
GO:0005829 cytosol CC
GO:0060174 limb bud formation BP
GO:0048514 blood vessel morphogenesis BP
GO:0007267 cell-cell signaling BP
GO:0005102 receptor binding MF
GO:0045844 positive regulation of striated muscle tissue development BP

Sequence

>gi|6753992|ref|NP_034418.1| gap junction alpha-1 protein [Mus musculus]
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSF
PISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIE
EHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFI
IFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSP
MSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAG
HELQPLAIVDQRPSSRASSRASSRPRPDDLEI

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Mm.378921
PDB
RefSeq NP_034418.1
Pfam PF03508
PF00029
PF10582