Connexin 43

General Information (Source: NCBI Gene,UniProt)

Text mining Term Connexin 43
UniProt ID CXA1_RAT
Name Cx43
Gap junction alpha-1 protein
Connexin-43
Gap junction 43 kDa heart protein
Gene Names Gja1
Taxonomy Rattus norvegicus

General annotation

Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular location Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Gene Ontology

GO:0008285 negative regulation of cell proliferation BP
GO:0016264 gap junction assembly BP
GO:0007267 cell-cell signaling BP
GO:0010232 vascular transport BP
GO:0005916 fascia adherens CC
GO:0005624 membrane fraction CC
GO:0045732 positive regulation of protein catabolic process BP
GO:0043434 response to peptide hormone stimulus BP
GO:0030165 PDZ domain binding MF
GO:0015867 ATP transport BP
GO:0051924 regulation of calcium ion transport BP
GO:0005741 mitochondrial outer membrane CC
GO:0006915 apoptotic process BP
GO:0005769 early endosome CC
GO:0005243 gap junction channel activity MF
GO:0005789 endoplasmic reticulum membrane CC
GO:0005764 lysosome CC
GO:0005771 multivesicular body CC
GO:0005887 integral to plasma membrane CC
GO:0005922 connexon complex CC
GO:0048812 neuron projection morphogenesis BP
GO:0017124 SH3 domain binding MF
GO:0045121 membrane raft CC
GO:0051259 protein oligomerization BP
GO:0009268 response to pH BP
GO:0030660 Golgi-associated vesicle membrane CC

Sequence

>gi|6978896|ref|NP_036699.1| gap junction alpha-1 protein [Rattus norvegicus]
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSF
PISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIE
EHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFI
IFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSP
MSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAG
HELQPLAIVDQRPSSRASSRASSRPRPDDLEI

Options for BLAST

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Database Cross Reference

Ensembl Gene ENSRNOT00000001054
UniGene Rn.10346
PDB 3CYY
1R5S
RefSeq NP_036699.1
Pfam PF10582
PF03508
PF00029