Connexin 43

General Information (Source: NCBI Gene,UniProt)

Text mining Term Connexin 43
UniProt ID A2AGI4_MOUSE
Name Gap junction protein
Gene Names Gjb1
Taxonomy Mus musculus

General annotation

Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity).
Subcellular location Membrane; Multi-pass membrane protein (By similarity).

Gene Ontology

GO:0042803 protein homodimerization activity MF
GO:0016021 integral to membrane CC
GO:0005922 connexon complex CC
GO:0007154 cell communication BP

Sequence

>gi|22165406|ref|NP_032150.2| gap junction beta-1 protein [Mus musculus]
MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDHFFP
ISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVV
FRLLFEAVFMYVFYLLYPGYAMVRLVKCEAFPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVV
YLIIRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRC
SAC

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Database Cross Reference

Ensembl Gene
UniGene Mm.21198
PDB
RefSeq NP_032150.2
Pfam PF10582
PF00029