| Text mining Term | PARP |
|---|---|
| UniProt ID | PARP_DROME |
| Name |
NAD(+) ADP-ribosyltransferase PARP Poly [ADP-ribose] polymerase ADPRT Poly[ADP-ribose] synthase |
| Gene Names |
Parp
|
| Taxonomy | Drosophila melanogaster |
| Function |
Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. Plays a fundamental role in organizing chromatin on a global scale; isoform e autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment. |
|---|---|
| Subcellular location |
Nucleus. Nucleus, nucleolus. Note=Highly enriched in nucleoli, heterochromatic chromosomal regions, and diverse euchromatic sites in the cells of most embryonic and adult tissues. |
| GO:0006963 | positive regulation of antibacterial peptide biosynthetic process | BP |
| GO:0043484 | regulation of RNA splicing | BP |
| GO:0006355 | regulation of transcription, DNA-dependent | BP |
| GO:0042393 | histone binding | MF |
| GO:0045087 | innate immune response | BP |
| GO:0051287 | NAD binding | MF |
| GO:0003677 | DNA binding | MF |
| GO:0005730 | nucleolus | CC |
| GO:0007000 | nucleolus organization | BP |
| GO:0007552 | metamorphosis | BP |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | MF |
| GO:0008270 | zinc ion binding | MF |
| GO:0051457 | maintenance of protein location in nucleus | BP |
| GO:0016568 | chromatin modification | BP |
| GO:0006471 | protein ADP-ribosylation | BP |
| GO:0009303 | rRNA transcription | BP |
| GO:0005719 | nuclear euchromatin | CC |
| GO:0005703 | polytene chromosome puff | CC |
| GO:0035080 | heat shock-mediated polytene chromosome puffing | BP |
>gi|548585|sp|P35875.1|PARP_DROME RecName: Full=Poly [ADP-ribose] polymerase; Short=PARP; AltName: Full=NAD(+) ADP-ribosyltransferase; Short=ADPRT; AltName: Full=Poly[ADP-ribose] synthase MDIELPYLAEYARTGRATCKGCKSTISKDTLRIAVMVQSAFHDAKVPNWFHKTCFFKNQRPSSVGDIQNI GNLRFADQKELTDLVENIQEVISAQLGKKRSKAFNLALKDFGIEYAKSSRSTCRGCEQKINKDLVRLRKT VYDTEVGMKYGGQPLWHHLECFAQLRSELGWFASGEDMPGFQSLADDDQAKVKNAIPPIKSEELPDTKRA KMELSDTNEEGEKKQRLKDQNDAYFRFRDDIKNKMKKKDIDILLKFNNQQPVTGDTEKLFDQTADLLTFG AIESCSECNSCQFIVNKSGYICNGNHSEWTKCNKLLKEPTRSACIVPKELKALYNFLNTVKEIPSTRIFN NFPPNKSTFSRSLLKTNKNNDVLVRPTIPRISPPLYNLKFSIIGLKNQHKELRKRIENLGGKFEVKISEN TIAIISTELEIQKKSTRMKFAEELGIHIVPIEFLDFVEADTEGAIKYINSTCICSWGTDPKSRIPKETTK SLNSNSIYTKSMPVSRTFKVKDGLAVDPDSGLEDIAHVYVDSNNKYSVVLGLTDIQRNKNSYYKVQLLKA DKKEKYWIFRSWGRIGTNIGNSKLEEFDTSESAKRNFKEIYADKTGNEYEQRDNFVKRTGRMYPIEIQYD DDQKLVKHESHFFTSKLEISVQNLIKLIFDIDSMNKTLMEFHIDMDKMPLGKLSAHQIQSAYRVVKEIYN VLECGSNTAKLIDATNRFYTLIPHNFGVQLPTLIETHQQIEDLRQMLDSLAEIEVAYSIIKSEDVSDACN PLDNHYAQIKTQLVALDKNSEEFSILSQYVKNTHASTHKSYDLKIVDVFKVSRQGEARRFKPFKKLHNRK LLWHGSRLTNFVGILSHGLRIAPPEAPPTGYMFGKGIYFADMVSKSANYCCTSQQNSTGLMLLSEVALGD MMECTSAKYINKLSNNKHSCFGRGRTMPDPTKSYIRSDGVEIPYGETITDEHLKSSLLYNEYIVYDVAQV NIQYLFRMEFKYSY |
| Ensembl Gene | |
|---|---|
| UniGene |
Dm.7847 |
| PDB | |
| RefSeq |
NP_001104452.1 |
| Pfam |
PF00644 PF08063 PF05406 PF00645 PF00533 PF02877 |