ERK1

General Information (Source: NCBI Gene,UniProt)

Text mining Term ERK1
UniProt ID ERKA_DROME
Name Mitogen-activated protein kinase ERK-A
Protein rolled
Extracellular-regulated kinase A
Gene Names rl
Synonyms:ERKa
Taxonomy Drosophila melanogaster

General annotation

Function Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways.
Subcellular location Cytoplasm. Nucleus.

Gene Ontology

GO:0071276 cellular response to cadmium ion BP
GO:0007369 gastrulation BP
GO:0006916 anti-apoptosis BP
GO:0008595 anterior/posterior axis specification, embryo BP
GO:0034614 cellular response to reactive oxygen species BP
GO:0050804 regulation of synaptic transmission BP
GO:0019901 protein kinase binding MF
GO:0005524 ATP binding MF
GO:0005634 nucleus CC
GO:0007474 imaginal disc-derived wing vein specification BP
GO:0034334 adherens junction maintenance BP
GO:0030054 cell junction CC
GO:0008293 torso signaling pathway BP
GO:0008284 positive regulation of cell proliferation BP
GO:0050803 regulation of synapse structure and activity BP
GO:0006974 response to DNA damage stimulus BP
GO:0007067 mitosis BP
GO:0006355 regulation of transcription, DNA-dependent BP
GO:0046534 positive regulation of photoreceptor cell differentiation BP
GO:0004705 JUN kinase activity MF
GO:0008134 transcription factor binding MF
GO:0048149 behavioral response to ethanol BP
GO:0007507 heart development BP
GO:0005737 cytoplasm CC
GO:0071243 cellular response to arsenic-containing substance BP
GO:0045467 R7 cell development BP

Sequence

>gi|161075905|ref|NP_001104349.1| rolled, isoform E [Drosophila melanogaster]
MEEFNSSGSVVNGTGSTEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS
PFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHIC
YFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE
IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESL
PFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINMENDD
ISRDALKSLIFEETLKFKERQPDNAP

Options for BLAST

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Database Cross Reference

Ensembl Gene
UniGene Dm.20303
PDB
RefSeq NP_001104348.1
NP_001015122.1
NP_001015123.1
NP_001015121.2
NP_001104349.1
Pfam PF00069