chemokines

General Information (Source: NCBI Gene,UniProt)

Text mining Term chemokines
UniProt ID GNAI_DROME
Name Guanine nucleotide-binding protein G(i) subunit alpha 65A
Gene Names
Taxonomy Drosophila melanogaster

General annotation

Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, G-oalpha47A and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord.
Subcellular location Cell membrane. Apical cell membrane. Note=Colocalizes with loco and raps/pins at the apical cortex throughout mitosis in neuroblasts.

Gene Ontology

GO:0032291 axon ensheathment in central nervous system BP
GO:0045167 asymmetric protein localization involved in cell fate determination BP
GO:0016324 apical plasma membrane CC
GO:0051294 establishment of spindle orientation BP
GO:0019991 septate junction assembly BP
GO:0046872 metal ion binding MF
GO:0004871 signal transducer activity MF
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger BP
GO:0005834 heterotrimeric G-protein complex CC
GO:0060857 establishment of glial blood-brain barrier BP
GO:0030866 cortical actin cytoskeleton organization BP
GO:0031683 G-protein beta/gamma-subunit complex binding MF
GO:0003924 GTPase activity MF
GO:0055059 asymmetric neuroblast division BP
GO:0008356 asymmetric cell division BP
GO:0014045 establishment of endothelial blood-brain barrier BP
GO:0005525 GTP binding MF
GO:0032880 regulation of protein localization BP
GO:0001664 G-protein coupled receptor binding MF
GO:0007419 ventral cord development BP
GO:0045179 apical cortex CC

Sequence

>gi|14286126|sp|P20353.2|GNAI_DROME RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha 65A
MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEY
RRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKKLWADGGVQQS
FARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLHFKLFDVGGQRSERK
KWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWFVETSIILFLNKKDLFEEKIK
RSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLK
QIGLF

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Database Cross Reference

Ensembl Gene
UniGene Dm.33467
PDB
RefSeq NP_477502.1
Pfam PF00503